Imbruvica (Ibrutinib)
Launch:
Imbruvica was launched by Pharmacyclics (now part of AbbVie) and Janssen Biotech in 2013.
Manufacturer:
AbbVie and Janssen Biotech
Global Sales in 2023:
Imbruvica generated approximately $9 billion in global sales in 2023.

Why It’s the Best:
: Imbruvica is a Bruton’s tyrosine kinase (BTK) inhibitor used in the treatment of various B-cell cancers, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Its ability to target cancer cells while sparing most normal cells has made it a breakthrough therapy in oncology. Imbruvica’s success in improving patient outcomes in difficult-to-treat cancers has solidified its place as a top-selling drug.